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Research Article

Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen

  • Jess H Leber,

    Affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America

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  • Gregory T Crimmins,

    Affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America

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  • Sridharan Raghavan,

    Affiliation: Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America

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  • Nicole P Meyer-Morse,

    Affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America

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  • Jeffery S Cox,

    Affiliation: Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America

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  • Daniel A Portnoy mail

    To whom correspondence should be addressed. E-mail: portnoy@uclink.berkeley.edu

    Affiliations: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America, School of Public Health, University of California, Berkeley, California, United States of America

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  • Published: January 11, 2008
  • DOI: 10.1371/journal.ppat.0040006

About the Authors

Jess H Leber, Gregory T Crimmins, Nicole P Meyer-Morse, Daniel A Portnoy
Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
Sridharan Raghavan, Jeffery S Cox
Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America
Daniel A Portnoy
School of Public Health, University of California, Berkeley, California, United States of America

Corresponding Author

Email: portnoy@uclink.berkeley.edu

Competing Interests

DAP has a consulting relationship with and a financial interest in Cerus Corporation, which may benefit from commercialization of the results of this research.

Author Contributions

JHL, GTC, SR, NPMM, JSC, and DAP conceived and designed the experiments. JHL, GTC, SR, and NPMM performed the experiments. JHL, GTC, SR, NPMM, JSC, and DAP analyzed the data. JHL and DAP wrote the paper.