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Research Article

Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68

  • Bonsu Ku equal contributor,

    equal contributor Contributed equally to this work with: Bonsu Ku, Jae-Sung Woo

    Affiliation: Division of Molecular and Life Sciences, Center for Biomolecular Recognition, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea

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  • Jae-Sung Woo equal contributor,

    equal contributor Contributed equally to this work with: Bonsu Ku, Jae-Sung Woo

    Affiliation: Division of Molecular and Life Sciences, Center for Biomolecular Recognition, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea

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  • Chengyu Liang,

    Affiliation: Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Kwang-Hoon Lee,

    Affiliation: Division of Molecular and Life Sciences, Center for Biomolecular Recognition, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea

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  • Hyang-Suk Hong,

    Affiliation: Division of Molecular and Life Sciences, Center for Biomolecular Recognition, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea

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  • Xiaofei E,

    Affiliation: Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Key-Sun Kim,

    Affiliation: Biomedical Research Center, Korea Institute of Science and Technology, Seoul, Korea

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  • Jae U Jung,

    Affiliation: Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Byung-Ha Oh mail

    To whom correspondence should be addressed. E-mail: bhoh@postech.ac.kr

    Affiliation: Division of Molecular and Life Sciences, Center for Biomolecular Recognition, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea

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  • Published: February 01, 2008
  • DOI: 10.1371/journal.ppat.0040025

About the Authors

Bonsu Ku, Jae-Sung Woo, Kwang-Hoon Lee, Hyang-Suk Hong, Byung-Ha Oh
Division of Molecular and Life Sciences, Center for Biomolecular Recognition, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea
Chengyu Liang, Xiaofei E, Jae U Jung
Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
Key-Sun Kim
Biomedical Research Center, Korea Institute of Science and Technology, Seoul, Korea

Corresponding Author

Email: bhoh@postech.ac.kr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BK, JSW, JUJ, and BHO conceived and designed the experiments. BK, JSW, CL, KHL, HSH, XE, and KSK performed the experiments. BK, JSW, JUJ, and BHO analyzed the data. BK, JSW, and BHO wrote the paper.