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Research Article

Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization

  • Joppe W. R Hovius equal contributor,

    equal contributor Contributed equally to this work with: Joppe W. R Hovius, Marein A. W. P de Jong

    Affiliations: Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam, The Netherlands

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  • Marein A. W. P de Jong equal contributor,

    equal contributor Contributed equally to this work with: Joppe W. R Hovius, Marein A. W. P de Jong

    Affiliation: Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands

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  • Jeroen den Dunnen,

    Affiliation: Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands

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  • Manja Litjens,

    Affiliation: Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands

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  • Erol Fikrig,

    Affiliation: Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Tom van der Poll,

    Affiliations: Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam, The Netherlands

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  • Sonja I Gringhuis,

    Affiliation: Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands

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  • Teunis B. H Geijtenbeek mail

    To whom correspondence should be addressed. E-mail: T.Geijtenbeek@VUMC.nl

    Affiliation: Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands

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  • Published: February 15, 2008
  • DOI: 10.1371/journal.ppat.0040031

About the Authors

Joppe W. R Hovius, Tom van der Poll
Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
Joppe W. R Hovius, Tom van der Poll
Center for Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam, The Netherlands
Marein A. W. P de Jong, Jeroen den Dunnen, Manja Litjens, Sonja I Gringhuis, Teunis B. H Geijtenbeek
Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands
Erol Fikrig
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

Corresponding Author

Email: T.Geijtenbeek@VUMC.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JWRH and MAWPJ conceived and designed the experiments, performed the experiments, analyzed the data, and wrote the paper. JD and ML performed experiments. EF and TVP contributed reagents/materials/analysis tools. SIG and TBHG conceived and designed the experiments, analyzed data, contributed reagents/materials/analysis tools, and wrote the paper.