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Research Article

Mucosal Damage and Neutropenia Are Required for Candida albicans Dissemination

  • Andrew Y Koh mail,

    To whom correspondence should be addressed. E-mail: Andrew_koh@dfci.harvard.edu

    Affiliations: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Hematology/Oncology, Children's Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Infectious Diseases, Children's Hospital, Boston, Massachusetts, United States of America, Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Julia R Köhler,

    Affiliation: Department of Medicine, Infectious Diseases, Children's Hospital, Boston, Massachusetts, United States of America

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  • Kathleen T Coggshall,

    Affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Nico Van Rooijen,

    Affiliation: Department of Cell Biology and Immunology, Free University, Amsterdam, The Netherlands

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  • Gerald B Pier

    Affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: February 15, 2008
  • DOI: 10.1371/journal.ppat.0040035

About the Authors

Andrew Y Koh, Kathleen T Coggshall, Gerald B Pier
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Andrew Y Koh
Department of Medicine, Hematology/Oncology, Children's Hospital, Boston, Massachusetts, United States of America
Andrew Y Koh, Julia R Köhler
Department of Medicine, Infectious Diseases, Children's Hospital, Boston, Massachusetts, United States of America
Andrew Y Koh
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
Nico Van Rooijen
Department of Cell Biology and Immunology, Free University, Amsterdam, The Netherlands

Corresponding Author

Email: Andrew_koh@dfci.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AYK conceived and designed the experiments, performed the experiments, analyzed the data, and wrote the paper. JRK provided C. albicans microbiological instruction and support. KTC performed the experiments. NVR provided the liposomal clodronate and instruction on dosing and methods for verification of macrophage depletion. GPB conceived and designed the experiments and analyzed the data.