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Research Article

Nucleotide Biosynthesis Is Critical for Growth of Bacteria in Human Blood

  • Shalaka Samant,

    Affiliation: Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Hyunwoo Lee,

    Affiliation: Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Mahmood Ghassemi,

    Affiliation: Section of Infectious Diseases, Immunology and Internal Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Juan Chen,

    Affiliation: Section of Infectious Diseases, Immunology and Internal Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • James L Cook,

    Affiliation: Section of Infectious Diseases, Immunology and Internal Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Alexander S Mankin mail,

    To whom correspondence should be addressed. E-mail: shura@uic.edu

    Affiliation: Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Alexander A Neyfakh

    Affiliation: Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Published: February 15, 2008
  • DOI: 10.1371/journal.ppat.0040037

About the Authors

Shalaka Samant, Hyunwoo Lee, Alexander S Mankin, Alexander A Neyfakh
Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, Illinois, United States of America
Mahmood Ghassemi, Juan Chen, James L Cook
Section of Infectious Diseases, Immunology and Internal Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: shura@uic.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SS, JLC, and AAN conceived and designed the experiments. SS, MG, and JC performed the experiments. HL, MG, JLC, and ASM analyzed the data. contributed reagents/materials/analysis tools. SS and ASM wrote the paper.