Advertisement
Research Article

IL-10 from CD4+CD25Foxp3CD127 Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection

  • Kevin N. Couper,

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

    X
  • Daniel G. Blount,

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

    Current address: School of Pharmacy, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Mark S. Wilson,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Julius C. Hafalla,

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

    X
  • Yasmine Belkaid,

    Affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Masahito Kamanaka,

    Affiliation: Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Richard A. Flavell,

    Affiliation: Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • J. Brian de Souza,

    Affiliations: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom

    X
  • Eleanor M. Riley mail

    eleanor.riley@lshtm.ac.uk

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

    X
  • Published: February 29, 2008
  • DOI: 10.1371/journal.ppat.1000004

About the Authors

Kevin N. Couper, Daniel G. Blount, Julius C. Hafalla, J. Brian de Souza, Eleanor M. Riley
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Mark S. Wilson, Yasmine Belkaid
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Masahito Kamanaka, Richard A. Flavell
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
J. Brian de Souza
Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom

Corresponding Author

Email: eleanor.riley@lshtm.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KC JdS ER. Performed the experiments: KC DB MW JH. Analyzed the data: KC DB MW. Contributed reagents/materials/analysis tools: YB MK RF. Wrote the paper: KC ER.