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Research Article

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

  • Caroline Sommereyns equal contributor,

    equal contributor Contributed equally to this work with: Caroline Sommereyns, Sophie Paul

    Affiliation: Université catholique de Louvain, de Duve Institute, MIPA-VIRO 74-49, Brussels, Belgium

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  • Sophie Paul equal contributor,

    equal contributor Contributed equally to this work with: Caroline Sommereyns, Sophie Paul

    Affiliation: Université catholique de Louvain, de Duve Institute, MIPA-VIRO 74-49, Brussels, Belgium

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  • Peter Staeheli,

    Affiliation: Department of Virology, University of Freiburg, Freiburg, Germany

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  • Thomas Michiels mail

    thomas.michiels@uclouvain.be

    Affiliation: Université catholique de Louvain, de Duve Institute, MIPA-VIRO 74-49, Brussels, Belgium

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  • Published: March 14, 2008
  • DOI: 10.1371/journal.ppat.1000017

About the Authors

Caroline Sommereyns, Sophie Paul, Thomas Michiels
Université catholique de Louvain, de Duve Institute, MIPA-VIRO 74-49, Brussels, Belgium
Peter Staeheli
Department of Virology, University of Freiburg, Freiburg, Germany

Corresponding Author

Email: thomas.michiels@uclouvain.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CS SP TM. Performed the experiments: CS SP PS TM. Analyzed the data: CS SP TM. Contributed reagents/materials/analysis tools: PS. Wrote the paper: CS SP PS TM. Performed and designed the experiments to define tissues and cells responding to IFNs: CS. Performed and designed the experiments destined to analyze IFN production: SP. Provided Mx-positive mice as well as antibodies, and performed the LACV infections: PS. Helped in the design and performance of several experiments, and wrote the manuscript with the help of all co-authors: TM.