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Research Article

Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage

  • Denis R. Chopera,

    Affiliation: Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Zenda Woodman,

    Affiliation: Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Koleka Mlisana,

    Affiliation: Centre for the AIDS Programme of Research in South Africa, University of Kwa-Zulu Natal, Durban, South Africa

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  • Mandla Mlotshwa,

    Affiliation: National Institute for Communicable Diseases, Johannesburg, South Africa

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  • Darren P. Martin,

    Affiliation: Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Cathal Seoighe,

    Affiliation: Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Florette Treurnicht,

    Affiliation: Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Debra Assis de Rosa,

    Affiliation: National Institute for Communicable Diseases, Johannesburg, South Africa

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  • Winston Hide,

    Affiliation: South African National Bioinformatics Institute, University of the Western Cape, Cape Town, South Africa

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  • Salim Abdool Karim,

    Affiliation: Centre for the AIDS Programme of Research in South Africa, University of Kwa-Zulu Natal, Durban, South Africa

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  • Clive M. Gray,

    Affiliation: National Institute for Communicable Diseases, Johannesburg, South Africa

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  • Carolyn Williamson mail,

    carolyn.williamson@uct.ac.za

    Affiliation: Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • and the CAPRISA 002 Study Team
  • Published: March 21, 2008
  • DOI: 10.1371/journal.ppat.1000033

About the Authors

Denis R. Chopera, Zenda Woodman, Darren P. Martin, Cathal Seoighe, Florette Treurnicht, Carolyn Williamson
Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Koleka Mlisana, Salim Abdool Karim
Centre for the AIDS Programme of Research in South Africa, University of Kwa-Zulu Natal, Durban, South Africa
Mandla Mlotshwa, Debra Assis de Rosa, Clive M. Gray
National Institute for Communicable Diseases, Johannesburg, South Africa
Winston Hide
South African National Bioinformatics Institute, University of the Western Cape, Cape Town, South Africa

Corresponding Author

Email: carolyn.williamson@uct.ac.za

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DC ZW KM SA CG CW. Performed the experiments: DC MM FT DA. Analyzed the data: DC ZW MM DM CS FT DA CG CW. Contributed reagents/materials/analysis tools: KM DM CS WH CG. Wrote the paper: DC ZW DM CS SA CG CW.