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Research Article

The Influence of Host and Bacterial Genotype on the Development of Disseminated Disease with Mycobacterium tuberculosis

  • Maxine Caws mail,

    mcaws@hotmail.com

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom

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  • Guy Thwaites,

    Affiliation: Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom

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  • Sarah Dunstan,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom

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  • Thomas R. Hawn,

    Affiliation: University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Nguyen Thi Ngoc Lan,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Nguyen Thuy Thuong Thuong,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam, The Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Kasia Stepniewska,

    Affiliation: Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom

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  • Mai Nguyet Thu Huyen,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Nguyen Duc Bang,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Tran Huu Loc,

    Affiliation: Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Sebastien Gagneux,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Dick van Soolingen,

    Affiliation: Tuberculosis Reference Laboratory, National Institute for Public Health, Bilthoeven, The Netherlands

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  • Kristin Kremer,

    Affiliation: Tuberculosis Reference Laboratory, National Institute for Public Health, Bilthoeven, The Netherlands

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  • Marianne van der Sande,

    Affiliation: Tuberculosis Reference Laboratory, National Institute for Public Health, Bilthoeven, The Netherlands

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  • Peter Small,

    Affiliations: Institute for Systems Biology, Seattle, Washington, United States of America, Bill and Melinda Gates Foundation, Seattle, Washington, United States of America

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  • Phan Thi Hoang Anh,

    Affiliation: Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Nguyen Tran Chinh,

    Affiliation: The Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Hoang Thi Quy,

    Affiliation: Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Nguyen Thi Hong Duyen,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Dau Quang Tho,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Nguyen T. Hieu,

    Affiliation: Hung Vuong Obstetric Hospital, Hung Vuong Street, Ho Chi Minh City, Vietnam

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  • Estee Torok,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom

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  • Tran Tinh Hien,

    Affiliation: The Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Nguyen Huy Dung,

    Affiliation: Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Nguyen Thi Quynh Nhu,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Phan Minh Duy,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Nguyen van Vinh Chau,

    Affiliation: The Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam

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  • Jeremy Farrar

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom

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  • Published: March 28, 2008
  • DOI: 10.1371/journal.ppat.1000034

About the Authors

Maxine Caws, Sarah Dunstan, Nguyen Thuy Thuong Thuong, Nguyen Thi Hong Duyen, Dau Quang Tho, Estee Torok, Nguyen Thi Quynh Nhu, Phan Minh Duy, Jeremy Farrar
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
Maxine Caws, Sarah Dunstan, Kasia Stepniewska, Estee Torok, Jeremy Farrar
Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
Guy Thwaites
Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom
Thomas R. Hawn
University of Washington School of Medicine, Seattle, Washington, United States of America
Nguyen Thi Ngoc Lan, Mai Nguyet Thu Huyen, Nguyen Duc Bang, Sebastien Gagneux, Peter Small
Institute for Systems Biology, Seattle, Washington, United States of America
Nguyen Thuy Thuong Thuong, Nguyen Tran Chinh, Tran Tinh Hien, Nguyen van Vinh Chau
The Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
Tran Huu Loc, Phan Thi Hoang Anh, Hoang Thi Quy, Nguyen Huy Dung
Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, District 5, Ho Chi Minh City, Vietnam
Dick van Soolingen, Kristin Kremer, Marianne van der Sande
Tuberculosis Reference Laboratory, National Institute for Public Health, Bilthoeven, The Netherlands
Peter Small
Bill and Melinda Gates Foundation, Seattle, Washington, United States of America
Nguyen T. Hieu
Hung Vuong Obstetric Hospital, Hung Vuong Street, Ho Chi Minh City, Vietnam

Corresponding Author

Email: mcaws@hotmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC GT SD TH JF. Performed the experiments: MC NT MH NB TL PA NH DT NQ PD. Analyzed the data: MC GT SD TH NT KS NB SG KK MvdS NH ET JF. Contributed reagents/materials/analysis tools: NL MH SG DvS KK MvdS PS NTC HQ NTH TT ND NV. Wrote the paper: MC GT SD TH SG MvdS ET JF.