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Research Article

Human-Like Receptor Specificity Does Not Affect the Neuraminidase-Inhibitor Susceptibility of H5N1 Influenza Viruses

  • Natalia A. Ilyushina,

    Affiliations: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Laboratory of Virus Physiology, The D.I. Ivanovsky Institute of Virology RAMS, Moscow, Russia

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  • Elena A. Govorkova,

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Thomas E. Gray,

    Affiliation: Laboratory of Molecular Carcinogenesis, National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Nicolai V. Bovin,

    Affiliation: Laboratory of Carbohydrate Chemistry, Shemyakin Institute of Bioorganic Chemistry, Moscow, Russia

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  • Robert G. Webster mail

    robert.webster@stjude.org

    Affiliations: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Published: April 11, 2008
  • DOI: 10.1371/journal.ppat.1000043

About the Authors

Natalia A. Ilyushina, Elena A. Govorkova, Robert G. Webster
Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Natalia A. Ilyushina
Laboratory of Virus Physiology, The D.I. Ivanovsky Institute of Virology RAMS, Moscow, Russia
Thomas E. Gray
Laboratory of Molecular Carcinogenesis, National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
Nicolai V. Bovin
Laboratory of Carbohydrate Chemistry, Shemyakin Institute of Bioorganic Chemistry, Moscow, Russia
Robert G. Webster
Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Corresponding Author

Email: robert.webster@stjude.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Designed, coordinated, and conducted all the experiments, and contributed to manuscript preparation: NI. Supervised the experiments with NHBE cells: TG. Synthesized sialoglycoconjugates with different inner saccharide residues used in this study to characterize the receptor specificity of recombinant H5N1 viruses: NB. Supervised the entire project, designed and coordinated most of the experiments, and contributed to manuscript preparation: EG and RW.