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Research Article

Identification of a Bacterial-Like HslVU Protease in the Mitochondria of Trypanosoma brucei and Its Role in Mitochondrial DNA Replication

  • Ziyin Li,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Megan E. Lindsay,

    Affiliation: Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Shawn A. Motyka,

    Affiliation: Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Paul T. Englund,

    Affiliation: Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Ching C. Wang mail

    ccwang@cgl.ucsf.edu

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Published: April 18, 2008
  • DOI: 10.1371/journal.ppat.1000048

About the Authors

Ziyin Li, Ching C. Wang
Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America
Megan E. Lindsay, Shawn A. Motyka, Paul T. Englund
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: ccwang@cgl.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZL ML SM PE. Performed the experiments: ZL ML SM. Analyzed the data: ZL ML PE CW. Wrote the paper: ZL PE CW.