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Research Article

Maturation of West Nile Virus Modulates Sensitivity to Antibody-Mediated Neutralization

  • Steevenson Nelson,

    Affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Christiane A. Jost,

    Affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Qinq Xu,

    Affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jessica Ess,

    Affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Julie E. Martin,

    Affiliation: Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Theodore Oliphant,

    Affiliations: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Stephen S. Whitehead,

    Affiliation: Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Anna P. Durbin,

    Affiliation: Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Barney S. Graham,

    Affiliation: Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Michael S. Diamond,

    Affiliations: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Theodore C. Pierson mail

    piersontc@mail.nih.gov

    Affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: May 09, 2008
  • DOI: 10.1371/journal.ppat.1000060

About the Authors

Steevenson Nelson, Christiane A. Jost, Qinq Xu, Jessica Ess, Theodore C. Pierson
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Julie E. Martin, Barney S. Graham
Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America
Theodore Oliphant, Michael S. Diamond
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
Theodore Oliphant, Michael S. Diamond
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Theodore Oliphant, Michael S. Diamond
Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Stephen S. Whitehead
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Anna P. Durbin
Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Corresponding Author

Email: piersontc@mail.nih.gov

Competing Interests

M.S.D. is a consultant for MacroGenics, Inc, which has licensed the E16 antibody for commercial use.

Author Contributions

Conceived and designed the experiments: SN CJ TP. Performed the experiments: SN CJ QX JE. Analyzed the data: SN CJ MD TP. Contributed reagents/materials/analysis tools: JM TO SW AD BG MD. Wrote the paper: SN MD TP.