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Research Article

Varicellovirus UL49.5 Proteins Differentially Affect the Function of the Transporter Associated with Antigen Processing, TAP

  • Danijela Koppers-Lalic equal contributor,

    equal contributor Contributed equally to this work with: Danijela Koppers-Lalic, Marieke C. Verweij

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

    Current address: Virus and Stem Cell Biology Lab, Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands

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  • Marieke C. Verweij equal contributor,

    equal contributor Contributed equally to this work with: Danijela Koppers-Lalic, Marieke C. Verweij

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Andrea D. Lipińska,

    Affiliation: Department of Molecular Virology, University of Gdańsk, Gdańsk, Poland

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  • Ying Wang,

    Affiliation: Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America

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  • Edwin Quinten,

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Eric A. Reits,

    Affiliation: Department of Cell Biology and Histology, Academic Medical Centre, Amsterdam, The Netherlands

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  • Joachim Koch,

    Affiliation: Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Frankfurt/Main, Germany

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  • Sandra Loch,

    Affiliation: Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Frankfurt/Main, Germany

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  • Marisa Marcondes Rezende,

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Franz Daus,

    Affiliation: Virus Discovery Unit, ASG-Lelystad, Lelystad, The Netherlands

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  • Krystyna Bieńkowska-Szewczyk,

    Affiliation: Department of Molecular Virology, University of Gdańsk, Gdańsk, Poland

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  • Nikolaus Osterrieder,

    Affiliations: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America, Institute for Virology, Berlin, Germany

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  • Thomas C. Mettenleiter,

    Affiliation: Institute of Molecular Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

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  • Mirjam H. M. Heemskerk,

    Affiliation: Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands

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  • Robert Tampé,

    Affiliation: Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Frankfurt/Main, Germany

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  • Jacques J. Neefjes,

    Affiliation: Department of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Shafiqul I. Chowdhury,

    Affiliation: Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America

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  • Maaike E. Ressing,

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Frans A. M. Rijsewijk,

    Affiliation: Virus Discovery Unit, ASG-Lelystad, Lelystad, The Netherlands

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  • Emmanuel J. H. J. Wiertz mail

    wiertz@lumc.nl

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Published: May 30, 2008
  • DOI: 10.1371/journal.ppat.1000080

About the Authors

Danijela Koppers-Lalic, Marieke C. Verweij, Edwin Quinten, Marisa Marcondes Rezende, Maaike E. Ressing, Emmanuel J. H. J. Wiertz
Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
Andrea D. Lipińska, Krystyna Bieńkowska-Szewczyk
Department of Molecular Virology, University of Gdańsk, Gdańsk, Poland
Ying Wang, Shafiqul I. Chowdhury
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America
Eric A. Reits
Department of Cell Biology and Histology, Academic Medical Centre, Amsterdam, The Netherlands
Joachim Koch, Sandra Loch, Robert Tampé
Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Frankfurt/Main, Germany
Franz Daus, Frans A. M. Rijsewijk
Virus Discovery Unit, ASG-Lelystad, Lelystad, The Netherlands
Nikolaus Osterrieder
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
Nikolaus Osterrieder
Institute for Virology, Berlin, Germany
Thomas C. Mettenleiter
Institute of Molecular Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
Mirjam H. M. Heemskerk
Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
Jacques J. Neefjes
Department of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Corresponding Author

Email: wiertz@lumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DK MV AL YW ER SC FR EW. Performed the experiments: DK MV AL YW EQ ER JK SL MM FD MH SC FR EW. Analyzed the data: DK MV AL YW EQ ER JK MM SC MR FR EW. Contributed reagents/materials/analysis tools: AL YW ER JK FD KB NO TM MH RT JN SC MR FR EW. Wrote the paper: DK MV FR EW.