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Research Article

Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

  • Tara J. Moriarty equal contributor,

    equal contributor Contributed equally to this work with: Tara J. Moriarty, M. Ursula Norman

    Affiliations: Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

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  • M. Ursula Norman equal contributor,

    equal contributor Contributed equally to this work with: Tara J. Moriarty, M. Ursula Norman

    Affiliation: Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada

    Current address: Centre for Inflammatory Diseases, Department of Medicine, Monash University, Victoria, Australia

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  • Pina Colarusso,

    Affiliation: Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada

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  • Troy Bankhead,

    Affiliations: Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

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  • Paul Kubes,

    Affiliation: Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada

    X
  • George Chaconas mail

    chaconas@ucalgary.ca

    Affiliations: Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

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  • Published: June 20, 2008
  • DOI: 10.1371/journal.ppat.1000090

About the Authors

Tara J. Moriarty, Troy Bankhead, George Chaconas
Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada
Tara J. Moriarty, Troy Bankhead, George Chaconas
Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
M. Ursula Norman, Pina Colarusso, Paul Kubes
Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada

Corresponding Author

Email: chaconas@ucalgary.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TM MN PK GC. Performed the experiments: TM MN TB. Analyzed the data: TM MN PC GC. Wrote the paper: TM MN PK GC.