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Research Article

RIG-I Mediates the Co-Induction of Tumor Necrosis Factor and Type I Interferon Elicited by Myxoma Virus in Primary Human Macrophages

  • Fuan Wang,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • Xiujuan Gao,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • John W. Barrett,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • Qing Shao,

    Affiliation: Department of Anatomy & Cell Biology, The University of Western Ontario, London, Ontario, Canada

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  • Eric Bartee,

    Affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Mohamed R. Mohamed,

    Affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Masmudur Rahman,

    Affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Steve Werden,

    Affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Timothy Irvine,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • Jingxin Cao,

    Affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Gregory A. Dekaban,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • Grant McFadden mail

    grantmcf@ufl.edu

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada, Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Published: July 11, 2008
  • DOI: 10.1371/journal.ppat.1000099

About the Authors

Fuan Wang, Xiujuan Gao, John W. Barrett, Timothy Irvine, Gregory A. Dekaban, Grant McFadden
BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
Fuan Wang, Xiujuan Gao, John W. Barrett, Timothy Irvine, Gregory A. Dekaban, Grant McFadden
Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada
Qing Shao
Department of Anatomy & Cell Biology, The University of Western Ontario, London, Ontario, Canada
Eric Bartee, Mohamed R. Mohamed, Masmudur Rahman, Steve Werden, Grant McFadden
Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
Jingxin Cao
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

Corresponding Author

Email: grantmcf@ufl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived of the project: FW GM. Performed the experiments: FW XG JB QS EB MM MR SW TI JC. Analyzed the data: FW XG JB QS EB MM MR SW TI JC GM. Wrote the paper: FW GD GM. Designed the experiments: FW XG JB QS EB MM MR SW TI JC GM.