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Research Article

Antibodies Targeting the PfRH1 Binding Domain Inhibit Invasion of Plasmodium falciparum Merozoites

  • Xiaohong Gao,

    Affiliation: Division of Genomics & Genetics, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Kim Pin Yeo,

    Affiliation: Division of Genomics & Genetics, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Siqi Sharon Aw,

    Affiliation: Division of Genomics & Genetics, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Claudia Kuss,

    Affiliation: Division of Genomics & Genetics, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Jayasree K. Iyer,

    Affiliation: Division of Genomics & Genetics, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Saraswathy Genesan,

    Affiliation: Division of Genomics & Genetics, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Ravikumar Rajamanonmani,

    Affiliation: Division of Structural & Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Julien Lescar,

    Affiliation: Division of Structural & Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Zbynek Bozdech,

    Affiliation: Division of Genomics & Genetics, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Peter R. Preiser mail

    PRPreiser@ntu.edu.sg

    Affiliation: Division of Genomics & Genetics, School of Biological Sciences, Nanyang Technological University, Singapore

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  • Published: July 11, 2008
  • DOI: 10.1371/journal.ppat.1000104

About the Authors

Xiaohong Gao, Kim Pin Yeo, Siqi Sharon Aw, Claudia Kuss, Jayasree K. Iyer, Saraswathy Genesan, Zbynek Bozdech, Peter R. Preiser
Division of Genomics & Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
Ravikumar Rajamanonmani, Julien Lescar
Division of Structural & Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore

Corresponding Author

Email: PRPreiser@ntu.edu.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XG PP. Performed the experiments: XG KY SA CK JI SG RR. Analyzed the data: XG KY CK RR JL ZB PP. Contributed reagents/materials/analysis tools: JI JL. Wrote the paper: XG JL ZB PP.