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Research Article

Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation

  • Caitlin O'Mahony,

    Affiliation: Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • Paul Scully,

    Affiliation: Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • David O'Mahony,

    Affiliation: Alimentary Health Ltd., University College Cork, Cork, Ireland

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  • Sharon Murphy,

    Affiliation: Alimentary Health Ltd., University College Cork, Cork, Ireland

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  • Frances O'Brien,

    Affiliation: Alimentary Health Ltd., University College Cork, Cork, Ireland

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  • Anne Lyons,

    Affiliation: Alimentary Health Ltd., University College Cork, Cork, Ireland

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  • Graham Sherlock,

    Affiliation: Alimentary Health Ltd., University College Cork, Cork, Ireland

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  • John MacSharry,

    Affiliation: Alimentary Health Ltd., University College Cork, Cork, Ireland

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  • Barry Kiely,

    Affiliation: Alimentary Health Ltd., University College Cork, Cork, Ireland

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  • Fergus Shanahan,

    Affiliation: Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • Liam O'Mahony mail

    liam.omahony@ucc.ie

    Affiliations: Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland, Alimentary Health Ltd., University College Cork, Cork, Ireland

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  • Published: August 01, 2008
  • DOI: 10.1371/journal.ppat.1000112

About the Authors

Caitlin O'Mahony, Paul Scully, Fergus Shanahan, Liam O'Mahony
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
David O'Mahony, Sharon Murphy, Frances O'Brien, Anne Lyons, Graham Sherlock, John MacSharry, Barry Kiely, Liam O'Mahony
Alimentary Health Ltd., University College Cork, Cork, Ireland

Corresponding Author

Email: liam.omahony@ucc.ie

Competing Interests

The authors are affiliated with a multi-departmental university campus-based research company (Alimentary Health Ltd.), which investigates host-flora interactions and the therapeutic manipulation of these interactions in various human and animal disorders. The content of this article was neither influenced nor constrained by this fact.

Author Contributions

Conceived and designed the experiments: CO JM BK FS LO. Performed the experiments: CO PS DO SM FO AL GS JM LO. Analyzed the data: CO PS DO SM AL GS JM LO. Contributed reagents/materials/analysis tools: LO. Wrote the paper: CO JM BK FS LO.