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Research Article

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

  • Lucy A. Perrone,

    Affiliation: Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Julie K. Plowden,

    Affiliation: Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Adolfo García-Sastre,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York, United States of America, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Jacqueline M. Katz,

    Affiliation: Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Terrence M. Tumpey mail

    tft9@cdc.gov

    Affiliation: Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Published: August 01, 2008
  • DOI: 10.1371/journal.ppat.1000115

About the Authors

Lucy A. Perrone, Julie K. Plowden, Jacqueline M. Katz, Terrence M. Tumpey
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Adolfo García-Sastre
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
Adolfo García-Sastre
Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York, United States of America
Adolfo García-Sastre
Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America

Corresponding Author

Email: tft9@cdc.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Designed and conducted the experiments: LAP TMT. Performed the flow cytometry: LAP JKP. Wrote the manuscript: LAP. Assisted with manuscript preparation: JKP AGS JMK TMT.