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Research Article

Temperature Shift and Host Cell Contact Up-Regulate Sporozoite Expression of Plasmodium falciparum Genes Involved in Hepatocyte Infection

  • Anthony Siau,

    Affiliations: INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris 6, UMR S511 Paris, France

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  • Olivier Silvie equal contributor,

    equal contributor Contributed equally to this work with: Olivier Silvie, Jean-François Franetich

    Affiliations: INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris 6, UMR S511 Paris, France

    These authors contributed equally to directing this work.

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  • Jean-François Franetich equal contributor,

    equal contributor Contributed equally to this work with: Olivier Silvie, Jean-François Franetich

    Affiliations: INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris 6, UMR S511 Paris, France

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  • Samir Yalaoui,

    Affiliations: INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris 6, UMR S511 Paris, France

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  • Carine Marinach,

    Affiliations: INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris 6, UMR S511 Paris, France

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  • Laurent Hannoun,

    Affiliation: Service de Chirurgie Digestive, Hépato-Bilio-Pancréatique et Transplantation Hépatique, Hôpital Pitié-Salpêtrière, Paris, France

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  • Geert-Jaan van Gemert,

    Affiliation: Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands

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  • Adrian J. F. Luty,

    Affiliation: Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands

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  • Emmanuel Bischoff,

    Affiliation: PF2-Genopole, Institut Pasteur, Paris France

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  • Peter H. David,

    Affiliation: Unité d'Immunologie Moléculaire des Parasites, CNRS URA 2581, Département de Parasitologie, Institut Pasteur, Paris, France

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  • Georges Snounou,

    Affiliation: Laboratoire de Parasitologie Comparée et Modèles Expérimentaux, Muséum National d'Histoire Naturelle, Paris, France

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  • Catherine Vaquero,

    Affiliations: INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris 6, UMR S511 Paris, France

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  • Patrick Froissard,

    Affiliations: INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris 6, UMR S511 Paris, France

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  • Dominique Mazier mail

    mazier@chups.jussieu.fr

    Affiliations: INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris 6, UMR S511 Paris, France, AP-HP, Groupe hospitalier Pitié-Salpêtrière, Service Parasitologie-Mycologie, Paris, France

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  • Published: August 08, 2008
  • DOI: 10.1371/journal.ppat.1000121

About the Authors

Anthony Siau, Olivier Silvie, Jean-François Franetich, Samir Yalaoui, Carine Marinach, Catherine Vaquero, Patrick Froissard, Dominique Mazier
INSERM, U511, Paris, France
Anthony Siau, Olivier Silvie, Jean-François Franetich, Samir Yalaoui, Carine Marinach, Catherine Vaquero, Patrick Froissard, Dominique Mazier
Université Pierre et Marie Curie-Paris 6, UMR S511 Paris, France
Laurent Hannoun
Service de Chirurgie Digestive, Hépato-Bilio-Pancréatique et Transplantation Hépatique, Hôpital Pitié-Salpêtrière, Paris, France
Geert-Jaan van Gemert, Adrian J. F. Luty
Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands
Emmanuel Bischoff
PF2-Genopole, Institut Pasteur, Paris France
Peter H. David
Unité d'Immunologie Moléculaire des Parasites, CNRS URA 2581, Département de Parasitologie, Institut Pasteur, Paris, France
Georges Snounou
Laboratoire de Parasitologie Comparée et Modèles Expérimentaux, Muséum National d'Histoire Naturelle, Paris, France
Dominique Mazier
AP-HP, Groupe hospitalier Pitié-Salpêtrière, Service Parasitologie-Mycologie, Paris, France

Corresponding Author

Email: mazier@chups.jussieu.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS OS GS CV PF DM. Performed the experiments: AS OS JFF SY. Analyzed the data: AS. Contributed reagents/materials/analysis tools: JFF SY CM LH GJvG AJFL EB PHD PF. Wrote the paper: AS GS. Revised drafts of the paper: OS JFF GJvG AJFL PHD CV DM.