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Research Article

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

  • Markus Mordstein,

    Affiliation: Department of Virology, University of Freiburg, Freiburg, Germany

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  • Georg Kochs,

    Affiliation: Department of Virology, University of Freiburg, Freiburg, Germany

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  • Laure Dumoutier,

    Affiliation: Ludwig Institute for Cancer Research, University of Louvain, Brussels, Belgium

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  • Jean-Christophe Renauld,

    Affiliation: Ludwig Institute for Cancer Research, University of Louvain, Brussels, Belgium

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  • Søren R. Paludan,

    Affiliation: Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark

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  • Kevin Klucher,

    Affiliation: ZymoGenetics, Inc., Seattle, Washington, United States of America

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  • Peter Staeheli mail

    peter.staeheli@uniklinik-freiburg.de

    Affiliation: Department of Virology, University of Freiburg, Freiburg, Germany

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  • Published: September 12, 2008
  • DOI: 10.1371/journal.ppat.1000151

About the Authors

Markus Mordstein, Georg Kochs, Peter Staeheli
Department of Virology, University of Freiburg, Freiburg, Germany
Laure Dumoutier, Jean-Christophe Renauld
Ludwig Institute for Cancer Research, University of Louvain, Brussels, Belgium
Søren R. Paludan
Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
Kevin Klucher
ZymoGenetics, Inc., Seattle, Washington, United States of America

Corresponding Author

Email: peter.staeheli@uniklinik-freiburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GK PS. Performed the experiments: MM PS. Analyzed the data: MM GK PS. Contributed reagents/materials/analysis tools: LD JCR SRP KK. Wrote the paper: PS.