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Research Article

Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization

  • Ying-Jie Lu equal contributor,

    equal contributor Contributed equally to this work with: Ying-Jie Lu, Jane Gross, Debby Bogaert

    Affiliation: Division of Infectious Diseases, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Jane Gross equal contributor,

    equal contributor Contributed equally to this work with: Ying-Jie Lu, Jane Gross, Debby Bogaert

    Affiliations: Division of Infectious Diseases, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary Medicine, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Debby Bogaert equal contributor,

    equal contributor Contributed equally to this work with: Ying-Jie Lu, Jane Gross, Debby Bogaert

    Affiliations: Division of Infectious Diseases, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America, Departments of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Adam Finn,

    Affiliation: Departments of Clinical Sciences at South Bristol, Academic Unit of Child Health, and of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

    X
  • Linda Bagrade,

    Affiliation: Departments of Clinical Sciences at South Bristol, Academic Unit of Child Health, and of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

    X
  • Qibo Zhang,

    Affiliation: Departments of Clinical Sciences at South Bristol, Academic Unit of Child Health, and of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

    X
  • Jay K. Kolls,

    Affiliation: Division of Pulmonology, Department of Pediatrics, Children's Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Amit Srivastava,

    Affiliation: Division of Infectious Diseases, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Anna Lundgren,

    Affiliation: Göteborg University Vaccine Research Institute (GUVAX), Department of Microbiology and Immunology, Institute of Biomedicine, Göteborg University, Sweden

    X
  • Sophie Forte,

    Affiliation: Division of Infectious Diseases, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Claudette M. Thompson,

    Affiliation: Departments of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Kathleen F. Harney,

    Affiliation: Department of Obstetrics and Gynecology, Cambridge Health Alliance, Cambridge, Massachusetts, United States of America

    X
  • Porter W. Anderson,

    Affiliation: Division of Infectious Diseases, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Marc Lipsitch ,

    Affiliation: Departments of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    Co-senior authors.

    X
  • Richard Malley mail

    richard.malley@childrens.harvard.edu

    Affiliation: Division of Infectious Diseases, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America

    Co-senior authors.

    X
  • Published: September 19, 2008
  • DOI: 10.1371/journal.ppat.1000159

About the Authors

Ying-Jie Lu, Jane Gross, Debby Bogaert, Amit Srivastava, Sophie Forte, Porter W. Anderson, Richard Malley
Division of Infectious Diseases, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
Jane Gross
Division of Pulmonary Medicine, Department of Medicine, Children's Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
Debby Bogaert, Claudette M. Thompson, Marc Lipsitch
Departments of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Adam Finn, Linda Bagrade, Qibo Zhang
Departments of Clinical Sciences at South Bristol, Academic Unit of Child Health, and of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
Jay K. Kolls
Division of Pulmonology, Department of Pediatrics, Children's Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Anna Lundgren
Göteborg University Vaccine Research Institute (GUVAX), Department of Microbiology and Immunology, Institute of Biomedicine, Göteborg University, Sweden
Kathleen F. Harney
Department of Obstetrics and Gynecology, Cambridge Health Alliance, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: richard.malley@childrens.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YJL JG DB AF LB QZ JKK AS AL CMT KFH PWA ML RM. Performed the experiments: YJL JG DB AF LB QZ AS AL SF CMT PWA ML RM. Analyzed the data: YJL JG DB AF LB QZ JKK AS AL SF CMT PWA ML RM. Contributed reagents/materials/analysis tools: YJL DB JKK KFH RM. Wrote the paper: PWA ML RM.