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Research Article

The Core and Accessory Genomes of Burkholderia pseudomallei: Implications for Human Melioidosis

  • Siew Hoon Sim equal contributor,

    equal contributor Contributed equally to this work with: Siew Hoon Sim, Yiting Yu

    Affiliation: Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore

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  • Yiting Yu equal contributor,

    equal contributor Contributed equally to this work with: Siew Hoon Sim, Yiting Yu

    Affiliation: Genome Institute of Singapore, Singapore, Republic of Singapore

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  • Chi Ho Lin,

    Affiliation: Genome Institute of Singapore, Singapore, Republic of Singapore

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  • R. Krishna M. Karuturi,

    Affiliation: Genome Institute of Singapore, Singapore, Republic of Singapore

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  • Vanaporn Wuthiekanun,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Apichai Tuanyok,

    Affiliation: Faculty of Medicine, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada

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  • Hui Hoon Chua,

    Affiliation: Genome Institute of Singapore, Singapore, Republic of Singapore

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  • Catherine Ong,

    Affiliation: Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore

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  • Sivalingam Suppiah Paramalingam,

    Affiliation: Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore

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  • Gladys Tan,

    Affiliation: Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore

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  • Lynn Tang,

    Affiliation: Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore

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  • Gary Lau,

    Affiliation: Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore

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  • Eng Eong Ooi,

    Affiliation: Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore

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  • Donald Woods,

    Affiliation: Faculty of Medicine, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada

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  • Edward Feil,

    Affiliation: Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom

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  • Sharon J. Peacock mail,

    sharon@tropmedres.ac (SJP); tanbop@gis.a-star.edu.sg (PT)

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, United Kingdom

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  • Patrick Tan mail

    sharon@tropmedres.ac (SJP); tanbop@gis.a-star.edu.sg (PT)

    Affiliations: Genome Institute of Singapore, Singapore, Republic of Singapore, Duke-NUS Graduate Medical School Singapore, Singapore, Republic of Singapore

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  • Published: October 17, 2008
  • DOI: 10.1371/journal.ppat.1000178

About the Authors

Siew Hoon Sim, Catherine Ong, Sivalingam Suppiah Paramalingam, Gladys Tan, Lynn Tang, Gary Lau, Eng Eong Ooi
Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore
Yiting Yu, Chi Ho Lin, R. Krishna M. Karuturi, Hui Hoon Chua, Patrick Tan
Genome Institute of Singapore, Singapore, Republic of Singapore
Vanaporn Wuthiekanun, Sharon J. Peacock
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Apichai Tuanyok, Donald Woods
Faculty of Medicine, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada
Edward Feil
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
Sharon J. Peacock
Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, United Kingdom
Patrick Tan
Duke-NUS Graduate Medical School Singapore, Singapore, Republic of Singapore

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SHS YY DW EF PT. Performed the experiments: SHS VW AT HHC CO SSP GT LT GL. Analyzed the data: SHS YY CHL RKMK VW DW EF SJP PT. Contributed reagents/materials/analysis tools: SHS CO EEO SJP PT. Wrote the paper: SHS YY CHL RKMK EEO DW EF SJP PT.