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Research Article

Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell Determinant

  • Noah S. Butler equal contributor,

    equal contributor Contributed equally to this work with: Noah S. Butler, Alex Theodossis

    Affiliations: Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America, Immunology Graduate Program, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Alex Theodossis equal contributor,

    equal contributor Contributed equally to this work with: Noah S. Butler, Alex Theodossis

    Affiliation: The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

    X
  • Andrew I. Webb,

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia

    X
  • Roza Nastovska,

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia

    X
  • Sri Harsha Ramarathinam,

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia

    X
  • Michelle A. Dunstone,

    Affiliation: The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

    X
  • Jamie Rossjohn,

    Affiliation: The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

    X
  • Anthony W. Purcell mail,

    apurcell@unimelb.edu.au (AWP); stanley-perlman@uiowa.edu (SP)

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia

    X
  • Stanley Perlman mail

    apurcell@unimelb.edu.au (AWP); stanley-perlman@uiowa.edu (SP)

    Affiliation: Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Published: October 24, 2008
  • DOI: 10.1371/journal.ppat.1000186

About the Authors

Noah S. Butler, Stanley Perlman
Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
Noah S. Butler
Immunology Graduate Program, University of Iowa, Iowa City, Iowa, United States of America
Alex Theodossis, Michelle A. Dunstone, Jamie Rossjohn
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
Andrew I. Webb, Roza Nastovska, Sri Harsha Ramarathinam, Anthony W. Purcell
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NSB AT JR AWP SP. Performed the experiments: NSB AT AIW RN SHR MAD. Analyzed the data: NSB AT MAD JR AWP SP. Contributed reagents/materials/analysis tools: AIW. Wrote the paper: NSB AT JR AWP SP.