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Research Article

Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection

  • Miguel Prudêncio equal contributor,

    equal contributor Contributed equally to this work with: Miguel Prudêncio, Cristina D. Rodrigues

    Affiliations: Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Cristina D. Rodrigues equal contributor,

    equal contributor Contributed equally to this work with: Miguel Prudêncio, Cristina D. Rodrigues

    Affiliations: Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Michael Hannus,

    Affiliation: Cenix BioScience GmbH, Dresden, Germany

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  • Cécilie Martin,

    Affiliation: Cenix BioScience GmbH, Dresden, Germany

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  • Eliana Real,

    Affiliation: Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal

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  • Lígia A. Gonçalves,

    Affiliation: Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Céline Carret,

    Affiliation: Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal

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  • Robert Dorkin,

    Affiliation: Alnylam Pharmaceuticals, Cambridge, Massachusetts, United States of America

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  • Ingo Röhl,

    Affiliation: Roche Kulmbach GmbH, Kulmbach, Germany

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  • Kerstin Jahn-Hoffmann,

    Affiliation: Roche Kulmbach GmbH, Kulmbach, Germany

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  • Adrian J. F. Luty,

    Affiliation: Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands

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  • Robert Sauerwein,

    Affiliation: Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands

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  • Christophe J. Echeverri,

    Affiliation: Cenix BioScience GmbH, Dresden, Germany

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  • Maria M. Mota mail

    mmota@fm.ul.pt

    Affiliations: Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Published: November 07, 2008
  • DOI: 10.1371/journal.ppat.1000201

About the Authors

Miguel Prudêncio, Cristina D. Rodrigues, Eliana Real, Céline Carret, Maria M. Mota
Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal
Miguel Prudêncio, Cristina D. Rodrigues, Lígia A. Gonçalves, Maria M. Mota
Instituto Gulbenkian de Ciência, Oeiras, Portugal
Michael Hannus, Cécilie Martin, Christophe J. Echeverri
Cenix BioScience GmbH, Dresden, Germany
Robert Dorkin
Alnylam Pharmaceuticals, Cambridge, Massachusetts, United States of America
Ingo Röhl, Kerstin Jahn-Hoffmann
Roche Kulmbach GmbH, Kulmbach, Germany
Adrian J. F. Luty, Robert Sauerwein
Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands

Corresponding Author

Email: mmota@fm.ul.pt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MP CDR MH CJE MMM. Performed the experiments: MP CDR CM ER LAG. Analyzed the data: MP CDR MH CM ER CC MMM. Contributed reagents/materials/analysis tools: RD KJH AJFL RWS CJE. Wrote the paper: MP CJE MMM.