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Research Article

Cryoelectron Tomography of HIV-1 Envelope Spikes: Further Evidence for Tripod-Like Legs

  • Ping Zhu,

    Affiliations: Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America, Center for Structural and Molecular Biology and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China

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  • Hanspeter Winkler,

    Affiliation: Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America

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  • Elena Chertova,

    Affiliation: AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Kenneth A. Taylor,

    Affiliation: Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America

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  • Kenneth H. Roux mail

    roux@bio.fsu.edu

    Affiliation: Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America

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  • Published: November 14, 2008
  • DOI: 10.1371/journal.ppat.1000203

About the Authors

Ping Zhu, Hanspeter Winkler, Kenneth A. Taylor, Kenneth H. Roux
Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America
Ping Zhu
Center for Structural and Molecular Biology and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China
Elena Chertova
AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

Corresponding Author

Email: roux@bio.fsu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KAT KHR. Performed the experiments: PZ. Analyzed the data: PZ HW KAT. Contributed reagents/materials/analysis tools: EC. Wrote the paper: KHR.