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Research Article

Key Role of Splenic Myeloid DCs in the IFN-αβ Response to Adenoviruses In Vivo

  • György Fejer mail,

    fejer@immunbio.mpg.de, gfejer@yahoo.com (GF); freudenberg@immunbio.mpg.de (MAF)

    Affiliation: Max-Planck-Institute for Immunobiology, Freiburg, Germany

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  • Lisa Drechsel,

    Affiliation: Max-Planck-Institute for Immunobiology, Freiburg, Germany

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  • Jan Liese,

    Affiliation: Institute of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany

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  • Ulrike Schleicher,

    Affiliation: Microbiology Institute - Clinical Microbiology, Immunology and Hygiene, University Clinic of Erlangen, Erlangen, Germany

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  • Zsolt Ruzsics,

    Affiliation: Max von Pettenkofer Institut für Virologie, Ludwig-Maximilians-Universität München, Munich, Germany

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  • Nicola Imelli,

    Affiliation: Institute of Zoology, University of Zurich, Zürich, Switzerland

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  • Urs F. Greber,

    Affiliation: Institute of Zoology, University of Zurich, Zürich, Switzerland

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  • Simone Keck,

    Affiliation: Max-Planck-Institute for Immunobiology, Freiburg, Germany

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  • Bernd Hildenbrand,

    Affiliation: Tumor Biology Center, Freiburg, Germany

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  • Anne Krug,

    Affiliation: Department of Internal Medicine, Technical University of Munich, Munich, Germany

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  • Christian Bogdan,

    Affiliation: Microbiology Institute - Clinical Microbiology, Immunology and Hygiene, University Clinic of Erlangen, Erlangen, Germany

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  • Marina A. Freudenberg mail

    fejer@immunbio.mpg.de, gfejer@yahoo.com (GF); freudenberg@immunbio.mpg.de (MAF)

    Affiliation: Max-Planck-Institute for Immunobiology, Freiburg, Germany

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  • Published: November 14, 2008
  • DOI: 10.1371/journal.ppat.1000208

About the Authors

György Fejer, Lisa Drechsel, Simone Keck, Marina A. Freudenberg
Max-Planck-Institute for Immunobiology, Freiburg, Germany
Jan Liese
Institute of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany
Ulrike Schleicher, Christian Bogdan
Microbiology Institute - Clinical Microbiology, Immunology and Hygiene, University Clinic of Erlangen, Erlangen, Germany
Zsolt Ruzsics
Max von Pettenkofer Institut für Virologie, Ludwig-Maximilians-Universität München, Munich, Germany
Nicola Imelli, Urs F. Greber
Institute of Zoology, University of Zurich, Zürich, Switzerland
Bernd Hildenbrand
Tumor Biology Center, Freiburg, Germany
Anne Krug
Department of Internal Medicine, Technical University of Munich, Munich, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GF US CB MAF. Performed the experiments: GF LD JL NI SK BH. Analyzed the data: GF LD JL US NI UFG SK MAF. Contributed reagents/materials/analysis tools: ZR UFG BH AK. Wrote the paper: GF MAF.