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Research Article

Role of Amphipathic Helix of a Herpesviral Protein in Membrane Deformation and T Cell Receptor Downregulation

  • Chan-Ki Min,

    Affiliation: Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Korea

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  • Sun-Young Bang,

    Affiliation: Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Korea

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  • Bon-A Cho,

    Affiliation: Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Korea

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  • Yun-Hui Choi,

    Affiliation: Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Korea

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  • Jae-Seong Yang,

    Affiliation: Department of Life Science and School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea

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  • Sun-Hwa Lee,

    Affiliation: Seoul National University Hospital, Innovative Research Institute for Cell Therapy, Chongno-Gu, Seoul, Korea

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  • Seung-Yong Seong,

    Affiliations: Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Korea, Seoul National University Hospital, Innovative Research Institute for Cell Therapy, Chongno-Gu, Seoul, Korea

    X
  • Ki Woo Kim,

    Affiliation: National Instrumentation Center for Environmental Management, Seoul National University, Gwanak-Gu, Seoul, Korea

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  • Sanguk Kim,

    Affiliation: Department of Life Science and School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea

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  • Jae Ung Jung,

    Affiliation: Department of Molecular Microbiology and Immunology, University of Southern California School of Medicine, Los Angeles, California, United States of America

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  • Myung-Sik Choi,

    Affiliation: Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Korea

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  • Ik-Sang Kim,

    Affiliation: Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Korea

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  • Nam-Hyuk Cho mail

    chonh@snu.ac.kr

    Affiliation: Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Korea

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  • Published: November 21, 2008
  • DOI: 10.1371/journal.ppat.1000209

About the Authors

Chan-Ki Min, Sun-Young Bang, Bon-A Cho, Yun-Hui Choi, Seung-Yong Seong, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho
Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul, Korea
Jae-Seong Yang, Sanguk Kim
Department of Life Science and School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea
Sun-Hwa Lee, Seung-Yong Seong
Seoul National University Hospital, Innovative Research Institute for Cell Therapy, Chongno-Gu, Seoul, Korea
Ki Woo Kim
National Instrumentation Center for Environmental Management, Seoul National University, Gwanak-Gu, Seoul, Korea
Jae Ung Jung
Department of Molecular Microbiology and Immunology, University of Southern California School of Medicine, Los Angeles, California, United States of America

Corresponding Author

Email: chonh@snu.ac.kr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CKM SHL SYS SK JUJ MSC ISK NHC. Performed the experiments: CKM SYB BAC YHC KWK NHC. Analyzed the data: CKM SYB JSY SYS SK JUJ MSC ISK NHC. Contributed reagents/materials/analysis tools: JSY SK. Wrote the paper: SHL JUJ NHC.