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Research Article

Vesicular Stomatitis Virus-Based Ebola Vaccine Is Well-Tolerated and Protects Immunocompromised Nonhuman Primates

  • Thomas W. Geisbert mail,

    geisbert@bu.edu

    Affiliations: National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, United States of America, Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Virology Division, BIOQUAL, Rockville, Maryland, United States of America

    X
  • Kathleen M. Daddario-DiCaprio,

    Affiliations: National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, United States of America, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Virology Division, BIOQUAL, Rockville, Maryland, United States of America

    X
  • Mark G. Lewis,

    Affiliation: BIOQUAL, Rockville, Maryland, United States of America

    X
  • Joan B. Geisbert,

    Affiliations: National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, United States of America, Virology Division, BIOQUAL, Rockville, Maryland, United States of America

    X
  • Allen Grolla,

    Affiliation: BIOQUAL, Rockville, Maryland, United States of America

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  • Anders Leung,

    Affiliation: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Jason Paragas,

    Affiliation: Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Lennox Matthias,

    Affiliation: BIOQUAL, Rockville, Maryland, United States of America

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  • Mark A. Smith,

    Affiliation: Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America

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  • Steven M. Jones,

    Affiliations: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada, Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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  • Lisa E. Hensley,

    Affiliation: Virology Division, BIOQUAL, Rockville, Maryland, United States of America

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  • Heinz Feldmann,

    Affiliations: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

    Current address: Laboratory of Virology, Division of Intramural Research, National Institutes of Allergy and Infectious Diseases Rocky Mountain Laboratories, Hamilton, Montana, United States of America

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  • Peter B. Jahrling

    Affiliations: Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: November 28, 2008
  • DOI: 10.1371/journal.ppat.1000225

About the Authors

Thomas W. Geisbert, Kathleen M. Daddario-DiCaprio, Joan B. Geisbert
National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, United States of America
Thomas W. Geisbert
Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Thomas W. Geisbert
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
Thomas W. Geisbert, Kathleen M. Daddario-DiCaprio
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
Thomas W. Geisbert, Peter B. Jahrling
Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Thomas W. Geisbert, Kathleen M. Daddario-DiCaprio, Joan B. Geisbert, Lisa E. Hensley
Virology Division, BIOQUAL, Rockville, Maryland, United States of America
Mark G. Lewis, Allen Grolla, Lennox Matthias
BIOQUAL, Rockville, Maryland, United States of America
Anders Leung, Steven M. Jones, Heinz Feldmann
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Jason Paragas, Peter B. Jahrling
Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Mark A. Smith
Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
Steven M. Jones
Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
Steven M. Jones, Heinz Feldmann
Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

Corresponding Author

Email: geisbert@bu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TWG HF PBJ. Performed the experiments: TWG KMDD MGL JBG AG AL LM LEH HF. Analyzed the data: TWG KMDD MGL JBG AG JP MAS SMJ LEH HF PBJ. Contributed reagents/materials/analysis tools: TWG SMJ LEH HF PBJ. Wrote the paper: TWG KMDD MGL HF.