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Research Article

A Structural Model of the Staphylococcus aureus ClfA–Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal Therapeutics

  • Vannakambadi K. Ganesh equal contributor,

    equal contributor Contributed equally to this work with: Vannakambadi K. Ganesh, Jose J. Rivera

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Jose J. Rivera equal contributor,

    equal contributor Contributed equally to this work with: Vannakambadi K. Ganesh, Jose J. Rivera

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    Current address: Department of Infectious Diseases and Employee Health, M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Emanuel Smeds,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Ya-Ping Ko,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • M. Gabriela Bowden,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Elisabeth R. Wann,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Shivasankarappa Gurusiddappa,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    Current address: Genomics and Proteomics Core Laboratory, Texas Children's Hospital, Houston, Texas, United States of America

    X
  • J. Ross Fitzgerald,

    Affiliation: Centre for Infectious Diseases, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Magnus Höök mail

    mhook@ibt.tamhsc.edu

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Published: November 28, 2008
  • DOI: 10.1371/journal.ppat.1000226

About the Authors

Vannakambadi K. Ganesh, Jose J. Rivera, Emanuel Smeds, Ya-Ping Ko, M. Gabriela Bowden, Elisabeth R. Wann, Shivasankarappa Gurusiddappa, Magnus Höök
Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America
J. Ross Fitzgerald
Centre for Infectious Diseases, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, United Kingdom

Corresponding Author

Email: mhook@ibt.tamhsc.edu

Competing Interests

A patent (pending) application has been filed based on some results in the manuscript.

Author Contributions

Conceived and designed the experiments: VKG JJR ES YPK MGB ERW JRF MH. Performed the experiments: VKG JJR ES YPK ERW SG. Analyzed the data: VKG JJR ES YPK ERW MH. Wrote the paper: VKG JJR ES YPK MGB JRF MH.