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Research Article

Identification of Tuberculosis Susceptibility Genes with Human Macrophage Gene Expression Profiles

  • Nguyen Thuy Thuong Thuong equal contributor,

    equal contributor Contributed equally to this work with: Nguyen Thuy Thuong Thuong, Sarah J. Dunstan

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Sarah J. Dunstan equal contributor mail,

    equal contributor Contributed equally to this work with: Nguyen Thuy Thuong Thuong, Sarah J. Dunstan

    sdunstan@oucru.org

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Tran Thi Hong Chau,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Vesteinn Thorsson,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Cameron P. Simmons,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Nguyen Than Ha Quyen,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Guy E. Thwaites,

    Affiliation: Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom

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  • Nguyen Thi Ngoc Lan,

    Affiliation: Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, Vietnam

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  • Martin Hibberd,

    Affiliation: Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore

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  • Yik Y. Teo,

    Affiliation: Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom

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  • Mark Seielstad,

    Affiliation: Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore

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  • Alan Aderem,

    Affiliation: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Jeremy J. Farrar,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Thomas R. Hawn

    Affiliation: University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Published: December 05, 2008
  • DOI: 10.1371/journal.ppat.1000229

About the Authors

Nguyen Thuy Thuong Thuong, Sarah J. Dunstan, Cameron P. Simmons, Nguyen Than Ha Quyen, Jeremy J. Farrar
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Nguyen Thuy Thuong Thuong, Tran Thi Hong Chau, Nguyen Than Ha Quyen
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Sarah J. Dunstan, Cameron P. Simmons, Jeremy J. Farrar
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom
Vesteinn Thorsson, Alan Aderem
Institute for Systems Biology, Seattle, Washington, United States of America
Guy E. Thwaites
Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom
Nguyen Thi Ngoc Lan
Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, Vietnam
Martin Hibberd, Mark Seielstad
Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore
Yik Y. Teo
Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom
Thomas R. Hawn
University of Washington School of Medicine, Seattle, Washington, United States of America

Corresponding Author

Email: sdunstan@oucru.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NTTT SJD TRH. Performed the experiments: NTTT. Analyzed the data: NTTT SJD VT MLH YYT MS JJF TRH. Contributed reagents/materials/analysis tools: SJD TTHC CPS NTHQ GET NTNL MLH MS AA TRH. Wrote the paper: NTTT SJD JJF TRH.