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Research Article

FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling

  • Ali A. Ashkar mail,

    ashkara@mcmaster.ca

    Affiliation: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Karen L. Mossman,

    Affiliations: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Brian K. Coombes,

    Affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Carlton L. Gyles,

    Affiliation: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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  • Randy Mackenzie

    Affiliation: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Published: December 05, 2008
  • DOI: 10.1371/journal.ppat.1000233

About the Authors

Ali A. Ashkar, Karen L. Mossman, Randy Mackenzie
Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Karen L. Mossman, Brian K. Coombes
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Carlton L. Gyles
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

Corresponding Author

Email: ashkara@mcmaster.ca

Competing Interests

We have filed a patent for the use of FimH as an innate microbicide.

Author Contributions

Conceived and designed the experiments: AAA. Performed the experiments: AAA KLM BKC RM. Analyzed the data: AAA KLM BKC. Contributed reagents/materials/analysis tools: CLG. Wrote the paper: AAA.