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Research Article

Immune Mechanisms Responsible for Vaccination against and Clearance of Mucosal and Lymphatic Norovirus Infection

  • Karen A. Chachu,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Anna D. LoBue,

    Affiliation: Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • David W. Strong,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Ralph S. Baric,

    Affiliation: Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Herbert W. Virgin mail

    virgin@wustl.edu

    Affiliations: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: December 12, 2008
  • DOI: 10.1371/journal.ppat.1000236

About the Authors

Karen A. Chachu, David W. Strong, Herbert W. Virgin
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Anna D. LoBue, Ralph S. Baric
Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Herbert W. Virgin
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Corresponding Author

Email: virgin@wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KAC ADL RSB SWV. Performed the experiments: KAC ADL DWS. Analyzed the data: KAC ADL RSB SWV. Wrote the paper: KAC ADL DWS RSB SWV.