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Research Article

Innate Invariant NKT Cells Recognize Mycobacterium tuberculosis–Infected Macrophages, Produce Interferon-γ, and Kill Intracellular Bacteria

  • Isabel Sada-Ovalle,

    Affiliations: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Immunochemistry Department, National Institute of Respiratory Diseases, Mexico City, Mexico

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  • Asako Chiba,

    Affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Adaena Gonzales,

    Affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Michael B. Brenner,

    Affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Samuel M. Behar mail

    sbehar@rics.bwh.harvard.edu

    Affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: December 12, 2008
  • DOI: 10.1371/journal.ppat.1000239

About the Authors

Isabel Sada-Ovalle, Asako Chiba, Adaena Gonzales, Michael B. Brenner, Samuel M. Behar
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Isabel Sada-Ovalle
Immunochemistry Department, National Institute of Respiratory Diseases, Mexico City, Mexico

Corresponding Author

Email: sbehar@rics.bwh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ISO AC SMB. Performed the experiments: ISO AC AG SMB. Analyzed the data: ISO SMB. Contributed reagents/materials/analysis tools: ISO AC MBB SMB. Wrote the paper: ISO MBB SMB.