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Research Article

Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae

  • Kimberly M. Davis,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Henry T. Akinbi,

    Affiliation: Divisions of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Alistair J. Standish,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Jeffrey N. Weiser mail

    weiser@mail.med.upenn.edu

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: December 12, 2008
  • DOI: 10.1371/journal.ppat.1000241

About the Authors

Kimberly M. Davis, Alistair J. Standish, Jeffrey N. Weiser
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Henry T. Akinbi
Divisions of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Corresponding Author

Email: weiser@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KMD AJS JNW. Performed the experiments: KMD. Analyzed the data: KMD JNW. Contributed reagents/materials/analysis tools: HTA. Wrote the paper: KMD JNW.