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Research Article

The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation

  • Jianmin Zuo,

    Affiliation: Cancer Research-UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Andrew Currin,

    Affiliation: Cancer Research-UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Bryan D. Griffin,

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Claire Shannon-Lowe,

    Affiliation: Cancer Research-UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Wendy A. Thomas,

    Affiliation: Cancer Research-UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Maaike E. Ressing,

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Emmanuel J. H. J. Wiertz,

    Affiliation: Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Martin Rowe mail

    m.rowe@bham.ac.uk

    Affiliation: Cancer Research-UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Published: January 02, 2009
  • DOI: 10.1371/journal.ppat.1000255

About the Authors

Jianmin Zuo, Andrew Currin, Claire Shannon-Lowe, Wendy A. Thomas, Martin Rowe
Cancer Research-UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Bryan D. Griffin, Maaike E. Ressing
Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
Emmanuel J. H. J. Wiertz
Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands

Corresponding Author

Email: m.rowe@bham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JZ CSL MR. Performed the experiments: JZ AC BG CSL WAT. Analyzed the data: JZ AC CSL MER EJHJW MR. Contributed reagents/materials/analysis tools: BG CSL MER EJHJW MR. Wrote the paper: JZ MR.