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Research Article

Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence

  • Sélène Ferrari,

    Affiliation: Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland

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  • Françoise Ischer,

    Affiliation: Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland

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  • David Calabrese,

    Affiliation: Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland

    Current address: Selexis SA, Plan-les-Ouates/Geneva, Switzerland

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  • Brunella Posteraro,

    Affiliation: Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy

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  • Maurizio Sanguinetti,

    Affiliation: Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy

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  • Giovanni Fadda,

    Affiliation: Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy

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  • Bettina Rohde,

    Affiliation: GATC Biotech AG, Konstanz, Germany

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  • Christopher Bauser,

    Affiliation: GATC Biotech AG, Konstanz, Germany

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  • Oliver Bader,

    Affiliation: Institut für Medizinische Mikrobiologie, Universitätskliniken Göttingen, Göttingen, Germany

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  • Dominique Sanglard mail

    dominique.sanglard@chuv.ch

    Affiliation: Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland

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  • Published: January 16, 2009
  • DOI: 10.1371/journal.ppat.1000268

About the Authors

Sélène Ferrari, Françoise Ischer, David Calabrese, Dominique Sanglard
Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland
Brunella Posteraro, Maurizio Sanguinetti, Giovanni Fadda
Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy
Bettina Rohde, Christopher Bauser
GATC Biotech AG, Konstanz, Germany
Oliver Bader
Institut für Medizinische Mikrobiologie, Universitätskliniken Göttingen, Göttingen, Germany

Corresponding Author

Email: dominique.sanglard@chuv.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SF MS DS. Performed the experiments: SF FI DC BP MS BR CB. Analyzed the data: SF BP MS BR CB DS. Contributed reagents/materials/analysis tools: GF OB. Wrote the paper: SF DS.