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Research Article

The IpaC Carboxyterminal Effector Domain Mediates Src-Dependent Actin Polymerization during Shigella Invasion of Epithelial Cells

  • Joëlle Mounier,

    Affiliations: Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France, Inserm U786, Institut Pasteur, Paris, France

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  • Michel R. Popoff,

    Affiliation: Unité de Recherche et d'Expertise Bactéries anaérobies et Toxines, Institut Pasteur, Paris, France

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  • Jost Enninga,

    Affiliations: Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France, Inserm U786, Institut Pasteur, Paris, France

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  • Margaret C. Frame,

    Affiliation: Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh, United Kingdom

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  • Philippe J. Sansonetti,

    Affiliations: Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France, Inserm U786, Institut Pasteur, Paris, France

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  • Guy Tran Van Nhieu mail

    gtranvan@pasteur.fr

    Affiliations: Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France, Inserm U786, Institut Pasteur, Paris, France

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  • Published: January 23, 2009
  • DOI: 10.1371/journal.ppat.1000271

About the Authors

Joëlle Mounier, Jost Enninga, Philippe J. Sansonetti, Guy Tran Van Nhieu
Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France
Joëlle Mounier, Jost Enninga, Philippe J. Sansonetti, Guy Tran Van Nhieu
Inserm U786, Institut Pasteur, Paris, France
Michel R. Popoff
Unité de Recherche et d'Expertise Bactéries anaérobies et Toxines, Institut Pasteur, Paris, France
Margaret C. Frame
Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh, United Kingdom

Corresponding Author

Email: gtranvan@pasteur.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GTVN. Performed the experiments: JM GTVN. Analyzed the data: JM MRP PJS GTVN. Contributed reagents/materials/analysis tools: MRP JE MCF GTVN. Wrote the paper: GTVN.