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Research Article

Immunization with Single-Cycle SIV Significantly Reduces Viral Loads After an Intravenous Challenge with SIVmac239

  • Bin Jia,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Sharon K. Ng,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • M. Quinn DeGottardi,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Michael Piatak Jr.,

    Affiliation: AIDS and Cancer Virus Program, SAIC Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Eloísa Yuste,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

    Current address: Retrovirology and Viral Immunology Laboratory, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain

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  • Angela Carville,

    Affiliation: Department of Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Keith G. Mansfield,

    Affiliation: Department of Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Wenjun Li,

    Affiliation: Biostatistics Research Group, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Barbra A. Richardson,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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  • Jeffrey D. Lifson,

    Affiliation: AIDS and Cancer Virus Program, SAIC Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • David T. Evans mail

    devans@hms.harvard.edu

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Published: January 23, 2009
  • DOI: 10.1371/journal.ppat.1000272

About the Authors

Bin Jia, Sharon K. Ng, M. Quinn DeGottardi, Eloísa Yuste, David T. Evans
Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
Michael Piatak Jr., Jeffrey D. Lifson
AIDS and Cancer Virus Program, SAIC Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America
Angela Carville, Keith G. Mansfield
Department of Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
Wenjun Li
Biostatistics Research Group, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Barbra A. Richardson
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: devans@hms.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DTE. Performed the experiments: BJ SKN MQD MPJ JDL. Analyzed the data: SKN MQD WL BAR. Contributed reagents/materials/analysis tools: EY JDL. Wrote the paper: BJ DTE. Performed clinical veterinary procedures: AC KGM.