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Research Article

Viral Mimicry of Cdc2/Cyclin-Dependent Kinase 1 Mediates Disruption of Nuclear Lamina during Human Cytomegalovirus Nuclear Egress

  • Sofia Hamirally equal contributor,

    equal contributor Contributed equally to this work with: Sofia Hamirally, Jeremy P. Kamil

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Biological Systems Group, Oxford BioMedica, Oxford, United Kingdom

    X
  • Jeremy P. Kamil equal contributor,

    equal contributor Contributed equally to this work with: Sofia Hamirally, Jeremy P. Kamil

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Yasmine M. Ndassa-Colday,

    Affiliations: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Alison J. Lin,

    Affiliations: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Wan Jin Jahng,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Departments of Ophthalmology and Pathology, Microbiology, and Immunology, University of South Carolina, Columbia, South Carolina, United States of America

    X
  • Moon-Chang Baek,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Department of Molecular Medicine, Kyungpook National University, Daegu, Korea

    X
  • Sarah Noton,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Laurie A. Silva,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Martha Simpson-Holley,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • David M. Knipe,

    Affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • David E. Golan,

    Affiliations: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Hematology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Jarrod A. Marto,

    Affiliations: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Donald M. Coen mail

    don_coen@hms.harvard.edu

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: January 23, 2009
  • DOI: 10.1371/journal.ppat.1000275

About the Authors

Sofia Hamirally, Jeremy P. Kamil, Yasmine M. Ndassa-Colday, Alison J. Lin, Wan Jin Jahng, Moon-Chang Baek, Sarah Noton, Laurie A. Silva, David E. Golan, Jarrod A. Marto, Donald M. Coen
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
Yasmine M. Ndassa-Colday, Jarrod A. Marto
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Alison J. Lin, David M. Knipe
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Martha Simpson-Holley
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
David E. Golan
Hematology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: don_coen@hms.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SH JPK YMNC AJL WJJ MCB LAS MSH DMK JAM DMC. Performed the experiments: SH JPK YMNC AJL WJJ MCB SN LAS MSH DMC. Analyzed the data: SH JPK YMNC AJL WJJ MCB SN LAS MSH DMK DEG JAM DMC. Contributed reagents/materials/analysis tools: DMK DEG JAM. Wrote the paper: SH JPK YMNC JAM DMC. Suggested revisions: WJJ SN LAS DMK DEG.