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Research Article

The Cell Adhesion Molecule “CAR” and Sialic Acid on Human Erythrocytes Influence Adenovirus In Vivo Biodistribution

  • Elena Seiradake equal contributor,

    equal contributor Contributed equally to this work with: Elena Seiradake, Daniel Henaff

    Affiliation: European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France

    X
  • Daniel Henaff equal contributor,

    equal contributor Contributed equally to this work with: Elena Seiradake, Daniel Henaff

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

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  • Harald Wodrich,

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

    X
  • Olivier Billet,

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

    X
  • Matthieu Perreau,

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

    X
  • Claire Hippert,

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

    X
  • Franck Mennechet,

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

    X
  • Guy Schoehn,

    Affiliation: Unit of Virus-Host Cell Interactions, UMR 5233, UJF-EMBL-CNRS, Grenoble, France

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  • Hugues Lortat-Jacob,

    Affiliation: Institut de Biologie Structurale, UMR 5075 CEA-CNRS-UJF, Grenoble, France

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  • Hanna Dreja,

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

    X
  • Sandy Ibanes,

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

    X
  • Vasiliki Kalatzis,

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

    X
  • Jennifer P. Wang,

    Affiliation: Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Robert W. Finberg,

    Affiliation: Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Stephen Cusack mail,

    cusack@embl.fr (SC); eric.kremer@igmm.cnrs.fr (EJK)

    Affiliations: European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France, Unit of Virus-Host Cell Interactions, UMR 5233, UJF-EMBL-CNRS, Grenoble, France

    X
  • Eric J. Kremer mail

    cusack@embl.fr (SC); eric.kremer@igmm.cnrs.fr (EJK)

    Affiliations: Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France, Universitiés Montpellier I & II, Montpellier, France

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  • Published: January 02, 2009
  • DOI: 10.1371/journal.ppat.1000277

About the Authors

Elena Seiradake, Stephen Cusack
European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France
Daniel Henaff, Harald Wodrich, Olivier Billet, Matthieu Perreau, Claire Hippert, Franck Mennechet, Hanna Dreja, Sandy Ibanes, Vasiliki Kalatzis, Eric J. Kremer
Institut de Génétique Moléculaire de Montpellier, CNRS 5535, Montpellier, France
Daniel Henaff, Harald Wodrich, Olivier Billet, Matthieu Perreau, Claire Hippert, Franck Mennechet, Hanna Dreja, Sandy Ibanes, Vasiliki Kalatzis, Eric J. Kremer
Universitiés Montpellier I & II, Montpellier, France
Guy Schoehn, Stephen Cusack
Unit of Virus-Host Cell Interactions, UMR 5233, UJF-EMBL-CNRS, Grenoble, France
Hugues Lortat-Jacob
Institut de Biologie Structurale, UMR 5075 CEA-CNRS-UJF, Grenoble, France
Jennifer P. Wang, Robert W. Finberg
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ES DH HW MP HLJ JPW SC EJK. Performed the experiments: ES DH HW OB MP CH FM GS HLJ HD SI VK. Analyzed the data: ES DH HW OB MP CH FM GS HLJ HD SI VK SC EJK. Contributed reagents/materials/analysis tools: JPW RF SC EJK. Wrote the paper: VK SC EJK.