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Research Article

Rotavirus NSP1 Inhibits NFκB Activation by Inducing Proteasome-Dependent Degradation of β-TrCP: A Novel Mechanism of IFN Antagonism

  • Joel W. Graff equal contributor,

    equal contributor Contributed equally to this work with: Joel W. Graff, Khalil Ettayebi

    Affiliation: Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America

    X
  • Khalil Ettayebi equal contributor,

    equal contributor Contributed equally to this work with: Joel W. Graff, Khalil Ettayebi

    Affiliation: Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America

    X
  • Michele E. Hardy mail

    mhardy@montana.edu

    Affiliation: Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America

    X
  • Published: January 30, 2009
  • DOI: 10.1371/journal.ppat.1000280

About the Authors

Joel W. Graff, Khalil Ettayebi, Michele E. Hardy
Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America

Corresponding Author

Email: mhardy@montana.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JWG KE MEH. Performed the experiments: JWG KE. Analyzed the data: JWG KE MEH. Wrote the paper: JWG KE MEH.