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Research Article

Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α Phosphorylation

  • Tetsuro Ikegami mail,

    teikegam@utmb.edu (TI); shmakino@utmb.edu (SM)

    Affiliations: Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Sealy Center for Vaccine Development, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America

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  • Krishna Narayanan,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America

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  • Sungyong Won,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America

    Current address: Department of Genetics, Scripps Research Institute, La Jolla, California, United States of America

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  • Wataru Kamitani,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America

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  • C. J. Peters,

    Affiliations: Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Sealy Center for Vaccine Development, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America

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  • Shinji Makino mail

    teikegam@utmb.edu (TI); shmakino@utmb.edu (SM)

    Affiliations: Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Sealy Center for Vaccine Development, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America

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  • Published: February 06, 2009
  • DOI: 10.1371/journal.ppat.1000287

About the Authors

Tetsuro Ikegami, Krishna Narayanan, Sungyong Won, Wataru Kamitani, C. J. Peters, Shinji Makino
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
Tetsuro Ikegami, C. J. Peters
Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
Tetsuro Ikegami, C. J. Peters, Shinji Makino
Sealy Center for Vaccine Development, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
Tetsuro Ikegami, C. J. Peters, Shinji Makino
Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TI SM. Performed the experiments: TI. Analyzed the data: TI KN CJP SM. Contributed reagents/materials/analysis tools: TI SW WK CJP SM. Wrote the paper: TI SM.