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Research Article

Phthiocerol Dimycocerosates of M. tuberculosis Participate in Macrophage Invasion by Inducing Changes in the Organization of Plasma Membrane Lipids

  • Catherine Astarie-Dequeker mail,

    catherine.astarie-dequeker@ipbs.fr (CAD); Christophe.Guilhot@ipbs.fr (CG)

    Affiliations: CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Laurent Le Guyader,

    Affiliations: CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Wladimir Malaga,

    Affiliations: CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Fam-Ky Seaphanh,

    Affiliations: CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Christian Chalut,

    Affiliations: CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • André Lopez,

    Affiliations: CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

    X
  • Christophe Guilhot mail

    catherine.astarie-dequeker@ipbs.fr (CAD); Christophe.Guilhot@ipbs.fr (CG)

    Affiliations: CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

    X
  • Published: February 06, 2009
  • DOI: 10.1371/journal.ppat.1000289

About the Authors

Catherine Astarie-Dequeker, Laurent Le Guyader, Wladimir Malaga, Fam-Ky Seaphanh, Christian Chalut, André Lopez, Christophe Guilhot
CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France
Catherine Astarie-Dequeker, Laurent Le Guyader, Wladimir Malaga, Fam-Ky Seaphanh, Christian Chalut, André Lopez, Christophe Guilhot
Université de Toulouse, UPS, IPBS, Toulouse, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CAD AL CG. Performed the experiments: CAD LlG WM FKS. Analyzed the data: CAD LlG. Contributed reagents/materials/analysis tools: LlG WM FKS CC. Wrote the paper: CAD AL CG.