Advertisement
Research Article

HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice

  • Michael A. Joyce mail,

    maj2@ualberta.ca

    Affiliation: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

    X
  • Kathie-Anne Walters,

    Affiliation: Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Sue-Ellen Lamb,

    Affiliation: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

    X
  • Mathew M. Yeh,

    Affiliation: Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Lin-Fu Zhu,

    Affiliation: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada

    X
  • Norman Kneteman,

    Affiliation: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada

    X
  • Jason S. Doyle,

    Affiliation: Department of Pathology, Vernon Jubilee Hospital, Vernon, British Columbia, Canada

    X
  • Michael G. Katze,

    Affiliation: Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • D. Lorne Tyrrell

    Affiliation: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

    X
  • Published: February 06, 2009
  • DOI: 10.1371/journal.ppat.1000291

About the Authors

Michael A. Joyce, Sue-Ellen Lamb, D. Lorne Tyrrell
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
Kathie-Anne Walters, Michael G. Katze
Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America
Mathew M. Yeh
Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, United States of America
Lin-Fu Zhu, Norman Kneteman
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
Jason S. Doyle
Department of Pathology, Vernon Jubilee Hospital, Vernon, British Columbia, Canada

Corresponding Author

Email: maj2@ualberta.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAJ KAW DLT. Performed the experiments: MAJ KAW SEL. Analyzed the data: MAJ KAW MMY JSD. Contributed reagents/materials/analysis tools: MAJ KAW LFZ NK MGK DLT. Wrote the paper: MAJ KAW DLT.