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Research Article

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

  • David Favre,

    Affiliation: Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America

    X
  • Sharon Lederer equal contributor,

    equal contributor Contributed equally to this work with: Sharon Lederer, Bittoo Kanwar, Zhong-Min Ma

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    X
  • Bittoo Kanwar equal contributor,

    equal contributor Contributed equally to this work with: Sharon Lederer, Bittoo Kanwar, Zhong-Min Ma

    Affiliations: Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco, California, United States of America

    X
  • Zhong-Min Ma equal contributor,

    equal contributor Contributed equally to this work with: Sharon Lederer, Bittoo Kanwar, Zhong-Min Ma

    Affiliation: Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, California, United States of America

    X
  • Sean Proll,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    X
  • Zeljka Kasakow,

    Affiliation: Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America

    X
  • Jeff Mold,

    Affiliation: Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America

    X
  • Louise Swainson,

    Affiliation: Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America

    X
  • Jason D. Barbour,

    Affiliation: Department of Medicine, HIV/AIDS Division, University of California, San Francisco, California, United States of America

    X
  • Carole R. Baskin,

    Affiliations: Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Washington National Primate Research Center, University of Washington, Seattle, Washington, United States of America

    X
  • Robert Palermo,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    X
  • Ivona Pandrea,

    Affiliation: Tulane National Primate Research Center, Covington, Louisiana, United States of America

    X
  • Christopher J. Miller,

    Affiliation: Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, California, United States of America

    X
  • Michael G. Katze,

    Affiliations: Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Washington National Primate Research Center, University of Washington, Seattle, Washington, United States of America

    X
  • Joseph M. McCune mail

    mike.mccune@ucsf.edu

    Affiliation: Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America

    X
  • Published: February 13, 2009
  • DOI: 10.1371/journal.ppat.1000295

About the Authors

David Favre, Bittoo Kanwar, Zeljka Kasakow, Jeff Mold, Louise Swainson, Joseph M. McCune
Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America
Sharon Lederer, Sean Proll, Carole R. Baskin, Robert Palermo, Michael G. Katze
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Bittoo Kanwar
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco, California, United States of America
Zhong-Min Ma, Christopher J. Miller
Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, California, United States of America
Jason D. Barbour
Department of Medicine, HIV/AIDS Division, University of California, San Francisco, California, United States of America
Carole R. Baskin, Michael G. Katze
Washington National Primate Research Center, University of Washington, Seattle, Washington, United States of America
Ivona Pandrea
Tulane National Primate Research Center, Covington, Louisiana, United States of America

Corresponding Author

Email: mike.mccune@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DF JMM. Performed the experiments: DF SLL BK ZMM ZK. Analyzed the data: DF SLL ZMM SP JDB. Contributed reagents/materials/analysis tools: DF BK JM LS CRB REP IP CJM MGK. Wrote the paper: DF JMM.