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Research Article

Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain Variants

  • Matthew W. McNatt,

    Affiliation: Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America

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  • Trinity Zang,

    Affiliations: Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America, Howard Hughes Medical Institute, New York, New York, United States of America

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  • Theodora Hatziioannou,

    Affiliation: Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America

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  • Mackenzie Bartlett,

    Affiliation: Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Ismael Ben Fofana,

    Affiliation: Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Welkin E. Johnson,

    Affiliation: Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Stuart J. D. Neil mail,

    stuart.neil@kcl.ac.uk (SJDN); pbienias@adarc.org (PDB)

    Affiliation: Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America

    Current address: Department of Infectious Disease, King's College London, Guy's Hospital, London, United Kingdom

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  • Paul D. Bieniasz mail

    stuart.neil@kcl.ac.uk (SJDN); pbienias@adarc.org (PDB)

    Affiliations: Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America, Howard Hughes Medical Institute, New York, New York, United States of America

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  • Published: February 13, 2009
  • DOI: 10.1371/journal.ppat.1000300

About the Authors

Matthew W. McNatt, Trinity Zang, Theodora Hatziioannou, Stuart J. D. Neil, Paul D. Bieniasz
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America
Trinity Zang, Paul D. Bieniasz
Howard Hughes Medical Institute, New York, New York, United States of America
Mackenzie Bartlett, Ismael Ben Fofana, Welkin E. Johnson
Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM TZ TH WEJ SJDN PDB. Performed the experiments: MM TZ TH MB IBF SJDN. Analyzed the data: MM TZ TH MB IBF WEJ SJDN PDB. Wrote the paper: MM WEJ PDB.