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Research Article

The Glutathione Biosynthetic Pathway of Plasmodium Is Essential for Mosquito Transmission

  • Joel Vega-Rodríguez,

    Affiliation: Department of Microbiology and Medical Zoology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico

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  • Blandine Franke-Fayard equal contributor,

    equal contributor Contributed equally to this work with: Blandine Franke-Fayard, Rhoel R. Dinglasan

    Affiliation: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

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  • Rhoel R. Dinglasan equal contributor,

    equal contributor Contributed equally to this work with: Blandine Franke-Fayard, Rhoel R. Dinglasan

    Affiliation: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United States of America

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  • Chris J. Janse,

    Affiliation: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

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  • Rebecca Pastrana-Mena,

    Affiliation: Department of Microbiology and Medical Zoology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico

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  • Andrew P. Waters,

    Affiliations: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands, Wellcome Trust Centre of Molecular Parasitology and Division of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom

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  • Isabelle Coppens,

    Affiliation: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United States of America

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  • José F. Rodríguez-Orengo,

    Affiliation: Department of Biochemistry, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico

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  • Marcelo Jacobs-Lorena,

    Affiliation: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United States of America

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  • Adelfa E. Serrano mail

    adelfa.serrano@upr.edu

    Affiliation: Department of Microbiology and Medical Zoology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico

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  • Published: February 20, 2009
  • DOI: 10.1371/journal.ppat.1000302

About the Authors

Joel Vega-Rodríguez, Rebecca Pastrana-Mena, Adelfa E. Serrano
Department of Microbiology and Medical Zoology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico
Blandine Franke-Fayard, Chris J. Janse, Andrew P. Waters
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Rhoel R. Dinglasan, Isabelle Coppens, Marcelo Jacobs-Lorena
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United States of America
Andrew P. Waters
Wellcome Trust Centre of Molecular Parasitology and Division of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom
José F. Rodríguez-Orengo
Department of Biochemistry, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico

Corresponding Author

Email: adelfa.serrano@upr.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JVR BFF RRD CJJ MJL AES. Performed the experiments: JVR BFF RRD CJJ RPM IC. Analyzed the data: JVR BFF RRD CJJ RPM APW IC JFRO MJL AES. Contributed reagents/materials/analysis tools: CJJ APW MJL AES. Wrote the paper: JVR AES. Revised the article critically: BFF RRD CJJ APW IC MJL.