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Research Article

KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA

  • Fang Cheng,

    Affiliation: Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland

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  • Magdalena Weidner-Glunde equal contributor,

    equal contributor Contributed equally to this work with: Magdalena Weidner-Glunde, Markku Varjosalo

    Affiliation: Institute of Virology, Hannover Medical School, Hannover, Germany

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  • Markku Varjosalo equal contributor,

    equal contributor Contributed equally to this work with: Magdalena Weidner-Glunde, Markku Varjosalo

    Affiliations: Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland, Department of Molecular Medicine, National Public Health Institute (KTL), Helsinki, Finland

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  • Eeva-Marja Rainio,

    Affiliations: Turku Centre for Biotechnology, BioCity, Turku, Finland, Department of Biology, University of Turku, Turku, Finland

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  • Anne Lehtonen,

    Affiliation: Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland

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  • Thomas F. Schulz,

    Affiliation: Institute of Virology, Hannover Medical School, Hannover, Germany

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  • Päivi J. Koskinen,

    Affiliations: Turku Centre for Biotechnology, BioCity, Turku, Finland, Department of Biology, University of Turku, Turku, Finland

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  • Jussi Taipale,

    Affiliations: Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland, Department of Molecular Medicine, National Public Health Institute (KTL), Helsinki, Finland

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  • Päivi M. Ojala mail

    paivi.ojala@helsinki.fi

    Affiliations: Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland, The Foundation for the Finnish Cancer Institute, Finland

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  • Published: March 06, 2009
  • DOI: 10.1371/journal.ppat.1000324

About the Authors

Fang Cheng, Markku Varjosalo, Anne Lehtonen, Jussi Taipale, Päivi M. Ojala
Genome-Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Magdalena Weidner-Glunde, Thomas F. Schulz
Institute of Virology, Hannover Medical School, Hannover, Germany
Markku Varjosalo, Jussi Taipale
Department of Molecular Medicine, National Public Health Institute (KTL), Helsinki, Finland
Eeva-Marja Rainio, Päivi J. Koskinen
Turku Centre for Biotechnology, BioCity, Turku, Finland
Eeva-Marja Rainio, Päivi J. Koskinen
Department of Biology, University of Turku, Turku, Finland
Päivi M. Ojala
The Foundation for the Finnish Cancer Institute, Finland

Corresponding Author

Email: paivi.ojala@helsinki.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FC MWG MV EMR AL TFS PJK JT PMO. Performed the experiments: FC MWG MV EMR. Analyzed the data: FC MWG EMR TFS PJK PMO. Contributed reagents/materials/analysis tools: MWG MV EMR AL TFS PJK JT. Wrote the paper: FC TFS PJK JT PMO. Provided the funding: PMO.