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Research Article

The Adenylate Cyclase Toxins of Bacillus anthracis and Bordetella pertussis Promote Th2 Cell Development by Shaping T Cell Antigen Receptor Signaling

  • Silvia Rossi Paccani,

    Affiliation: Department of Evolutionary Biology, University of Siena, Siena, Italy

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  • Marisa Benagiano,

    Affiliation: Department of Internal Medicine and Immunoallergology, University of Florence, Florence, Italy

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  • Nagaja Capitani,

    Affiliation: Department of Evolutionary Biology, University of Siena, Siena, Italy

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  • Irene Zornetta,

    Affiliation: Department of Biomedical Sciences, University of Padua, Padua, Italy

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  • Daniel Ladant,

    Affiliation: Unité de Biochimie des Interactions Macromoléculaires, CNRS URA 2185, Institut Pasteur, Paris, France

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  • Cesare Montecucco,

    Affiliation: Department of Biomedical Sciences, University of Padua, Padua, Italy

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  • Mario M. D'Elios,

    Affiliation: Department of Internal Medicine and Immunoallergology, University of Florence, Florence, Italy

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  • Cosima T. Baldari mail

    baldari@unisi.it

    Affiliation: Department of Evolutionary Biology, University of Siena, Siena, Italy

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  • Published: March 06, 2009
  • DOI: 10.1371/journal.ppat.1000325

About the Authors

Silvia Rossi Paccani, Nagaja Capitani, Cosima T. Baldari
Department of Evolutionary Biology, University of Siena, Siena, Italy
Marisa Benagiano, Mario M. D'Elios
Department of Internal Medicine and Immunoallergology, University of Florence, Florence, Italy
Irene Zornetta, Cesare Montecucco
Department of Biomedical Sciences, University of Padua, Padua, Italy
Daniel Ladant
Unité de Biochimie des Interactions Macromoléculaires, CNRS URA 2185, Institut Pasteur, Paris, France

Corresponding Author

Email: baldari@unisi.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SRP CM MMD CTB. Performed the experiments: SRP MB NC IZ. Analyzed the data: SRP MB NC CM MMD CTB. Contributed reagents/materials/analysis tools: IZ DL. Wrote the paper: DL CM MMD CTB.