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Research Article

An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt Lymphomagenesis: The Wp/BHRF1 Link

  • Gemma L. Kelly,

    Affiliation: Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Heather M. Long,

    Affiliation: Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Julianna Stylianou,

    Affiliation: Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Wendy A. Thomas,

    Affiliation: Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Alison Leese,

    Affiliation: Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Andrew I. Bell,

    Affiliation: Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Georg W. Bornkamm,

    Affiliation: GSF-Institut fur Klinische Molekularbiologie und Tumorgenetik GSF-Forschungszentrum fur Umwelt und Gesundheit, Munich, Germany

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  • Josef Mautner,

    Affiliation: Munich University of Technology, Children's Hospital, Munich, Germany

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  • Alan B. Rickinson mail,

    a.b.rickinson@bham.ac.uk

    Affiliation: Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Martin Rowe

    Affiliation: Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom

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  • Published: March 13, 2009
  • DOI: 10.1371/journal.ppat.1000341

About the Authors

Gemma L. Kelly, Heather M. Long, Julianna Stylianou, Wendy A. Thomas, Alison Leese, Andrew I. Bell, Alan B. Rickinson, Martin Rowe
Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom
Georg W. Bornkamm
GSF-Institut fur Klinische Molekularbiologie und Tumorgenetik GSF-Forschungszentrum fur Umwelt und Gesundheit, Munich, Germany
Josef Mautner
Munich University of Technology, Children's Hospital, Munich, Germany

Corresponding Author

Email: a.b.rickinson@bham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GLK HML ABR MR. Performed the experiments: GLK HML JS WAT AL. Analyzed the data: GLK HML. Contributed reagents/materials/analysis tools: GLK AIB GWB JM. Wrote the paper: GLK ABR MR.